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Research & Development
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Senior Computational Scientist (NCI)



The Basic Science Program (BSP) pursues independent, multidisciplinary research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics.  Research efforts and support are an integral part of the Center for Cancer Research (CCR) at the Frederick National Laboratory for Cancer Research (FNLCR).  The Cancer & Inflammation Program (CIP), Basic Science Program, HLA Immunogenetics Section, under the leadership of Dr. Mary Carrington, studies the influence of human leukocyte antigens (HLA) and specific KIR/HLA genotypes on risk of and outcomes to infection, cancer, autoimmune disease, and maternal-fetal disease. Recent studies have focused on the impact of HLA gene expression in disease, the molecular mechanism regulating expression levels, and the functional basis for the effect of differential expression on disease outcome.  The lab's further focus is on the genetic basis for resistance/susceptibility to disease conferred by immunogenetic variation.


The Senior Computational Scientist will provide research support to the CIP-BSP-HLA Immunogenetics Section performing bio-statistical design, analysis and reporting of research projects conducted in the lab.  This individual will be involved in the implementation of statistical models and data preparation.

  • Successful candidate should have 5 or more years of competent, innovative biostatistics/bioinformatics research experience, beyond doctoral training.
  • Considerable experience with statistical software, such as SAS, R and S-Plus.
  • Sound knowledge, and demonstrated experience of theoretical and applied statistics.
  • Write program code to analyze data using statistical analysis software.
  • Contribute to the interpretation and publication of research results.



To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a doctoral degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to educational requirements, a minimum of five (5) years of competent, innovative biostatistics/bioinformatics research experience.
  • Proficiency in developing test or production methods or protocols in an applied area.
  • Demonstrated ability to manage a production operation or a segment of a specialized service area. 
  • Must be familiar with computational tools such as GATK and SAMtools available for molecular modeling.  This will include a detailed knowledge of the use of currently available commercial tools for structural analysis as well as the capability to develop novel computational tools or specific tasks.
  • Experience with statistical software, such as SAS, R and S-Plus.
  • Must be able to obtain and maintain a security clearance.


Candidates with these desired skills will be given preferential consideration:

  • Experience with computational protocols, experience developing, implementing, and using databases such as dbGAP, SRA and GEO.
  • Able to analyze data using statistical approaches such as longitudinal analysis, mixed effects modelling, logistic regression analyses.
  • Provide biostatistical consultation to colleagues.
  • Keep abreast of methodological/conceptual developments in biostatistics. Ability to perform complex statistical analyses.

  • Demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought.
  • Exercises judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions. Expert knowledge of scientific principles and concepts.

Leidos Overview:
Leidos is a global science and technology solutions leader working to solve the world's toughest challenges in the defense, intelligence, homeland security, civil, and health markets. The company's 33,000 employees support vital missions for government and commercial customers. Headquartered in Reston, Virginia, Leidos reported pro forma annual revenues of approximately $10 billion for the fiscal year ended January 1, 2016 after giving effect to the recently completed combination of Leidos with Lockheed Martin's Information Systems & Global Solutions business (IS&GS). For more information, visit The company's diverse employees support vital missions for government and commercial customers. Qualified women, minorities, individuals with disabilities and protected veterans are encouraged to apply. Leidos will consider qualified applicants with criminal histories for employment in accordance with relevant Laws. Leidos is an Equal Opportunity Employer.

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